The goldenseal (berberine)/cyclosporine drug interaction

Goldenseal (Hydrastis canadensis) is promoted for a variety of uses. The active components are hydrastine and berberine. Both inhibit the liver metabolizing enzyme system known as cytochrome P450. Therefore, people treated the immunosuppressant, cyclosporine A (CsA; Sandimmune) and taking this herbal or berberine are at risk of a drug interaction. Here’s what we know based … Continue reading The goldenseal (berberine)/cyclosporine drug interaction