Category Archives: Berberine (Goldenseal)

Potential for berberine to cause drug interactions

Berberine is used to treat gastrointestinal infections, diabetes, high blood pressure, and cholesterol. Many studies report interactions between berberine-containing products and cytochrome P450, but little is known about whether berberine alters CYP activities in humans.

Researchers at the Xiang Ya School of Medicine, in the People’s Republic of China, studied the effects of berberine on a series of drugs and P450 enzymes after repeated dosing. Continue reading Potential for berberine to cause drug interactions

Berberine to treat acute coronary syndrome

Acute coronary syndrome refers to any condition brought on by sudden, reduced blood flow to the heart causing chest pain during a heart attack or chest pain at rest or doing light physical activity (unstable angina).

Researchers at Shanghai Jiaotong University, School of Medicine, in China, tested berberine’s effects on ACS patients following percutaneous coronary intervention (PCI) (aka angioplasty or stent placement). Continue reading Berberine to treat acute coronary syndrome

CYP2D6-mediated herb-drug interactions

Cytochrome P450 2D6 (CYP2D6) is a liver enzyme responsible for the metabolism of approximately 30% of all drugs.

Researchers at the University of Arkansas for Medical Sciences in Little Rock studied the effect of CYP2D6 on the metabolism of several herbal supplements and the risk of drug interactions. Continue reading CYP2D6-mediated herb-drug interactions

Treating kids with high cholesterol

Recently, the American Academy of Pediatrics published guidelines for screening children for high cholesterol blood levels.

Now, researchers from the Centers for Disease Control and Prevention in Atlanta, Georgia have estimated the number that might need treatment. Continue reading Treating kids with high cholesterol

CAM and diabetes: An update of recent studies

The World Health Organization has predicted a 39% rise in the worldwide prevalence of diabetes by 2030. And an article in The Lancet indicates this might be an underestimation.

Since November is Diabetes Month, here’s a round-up of CAM options for people with diabetes from 2006 through March 2007.
Continue reading CAM and diabetes: An update of recent studies

The goldenseal (berberine)/cyclosporine drug interaction

Goldenseal (Hydrastis canadensis) is promoted for a variety of uses. The active components are hydrastine and berberine. Both inhibit the liver metabolizing enzyme system known as cytochrome P450. Therefore, people treated the immunosuppressant, cyclosporine A (CsA; Sandimmune) and taking this herbal or berberine are at risk of a drug interaction.

Here’s what we know based on studies at the Wuhan General Hospital in Wuhan, China. Continue reading The goldenseal (berberine)/cyclosporine drug interaction

Prevalence of diabetes in the US in 2006

The Centers for Disease Control has just published the latest data on the prevalence of diabetes in the US.

  • 11% of adults aged 40 to 59 years
  • 23% of those 60 and older have diabetes

Is it any wonder that so many CAM therapies are studied in people with diabetes?

A quick listing of CAM entries for diabetes on this blog is provided below. Or, click the button on the right sidebar to see all of the diabetes entries.

Continue reading Prevalence of diabetes in the US in 2006