Category Archives: G. BOTANICALS

Acne treatments

The surest way to know that there is no truly effective treatment for a condition is to count the number of treatment recommendations. The more recommendations, the less likely it is that any of them have a significant effect. I’m not sure if there is a tipping point. Whether 6 or 12 or 20 recommended treatments guarantee that you will have less than complete cure.

Here are some of the recommendations from just one article.

Continue reading Acne treatments

Avoid marijuana during pregnancy and breast feeding

The American College of Obstetricians and Gynecologists (ACOG) has published its position on use of pot during pregnancy and breast-feeding.

The bottom line.

Yes, there are limitations in the available data about marijuana’s effects on the fetus during pregnancy and on the neonate during lactation. However, ACOG has seen enough to recommend that during pregnancy and during breast feeding to advise “discontinuation of maternal use [of marijuana], whether recreational or medicinal.”

There are no FDA-approved indications regarding marijuana use during pregnancy and lactation. Also, there are no standardized formulations, dosages, or delivery systems. Smoking, the most common route of administration of THC, cannot be medically condoned during pregnancy and lactation, according to ACOG.

The use of marijuana during pregnancy is associated with lower scores on tests of attention, coordination, and behavior in offspring.

6/25/15 JR

Up in smoke: Medical marijuana debunked

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Proponents of the use of medical marijuana like to start speeches and articles by quickly stating that cannabinoids are of proven value in treating many diseases.

Poppycock. This site has stated repeatedly: not true, not true, not true.

Now the evidence is in, and we were right. JAMA confirms that the evidence supporting the effectiveness of cannabinoids is tenuous at best. And risk of side effects with cannabinoids to treat anything is high.

Continue reading Up in smoke: Medical marijuana debunked

Milk thistle interaction with raloxifene (Evista)

milk_thistleRaloxifene is a selective estrogen receptor modulator (SERM) that is used to reduce the risk of invasive breast cancer in postmenopausal women with osteoporosis.

Researchers at Washington State University and the University of North Carolina at Greensboro evaluated the inhibitory effects of individual milk thistle constituents on the intestinal glucuronidation (detoxification) of raloxifene.

First, the details.

  • The inhibitory effects of individual milk thistle constituents on the intestinal metabolism of raloxifene were studied in the lab.
  • UDP-glucuronosyltransferase 1-1 (also known as UGT-1A) is an enzyme in human intestines, which along with UGT1A8, and UGT1A10 are critical to metabolizing and removing raloxifene from the body.

And, the results.

  • Milk thistle components silybin A and silybin B were potent inhibitors of raloxifene metabolism.

The bottom line?

The authors concluded: “Silibinin and silymarin [the major active constituents] were predicted to increase raloxifene systemic exposure by about 5-fold, indicating a high risk of interaction. Safety of raloxifene is discussed here.

It’s understandable that these women seek CAM, including herbals, to supplement raloxifene treatment.

It needs to be studied in humans, but for now, the risk of taking milk thistle would seem to outweigh any potential benefits. Check with your healthcare professional.

6/20/15 JR

 

Interaction of Ginkgo biloba with antiplatelet drugs

little-guy2Back in the ‘90s there were several reports of serious interactions in people who used Ginkgo biloba with other “blood thinners” to treat peripheral vascular disease (ie, dementia and claudication).

Researchers at Inje University College of Medicine, in Busan, Republic of Korea, evaluated the effects of G. biloba extracts on the pharmacokinetics of the antiplatelet drug cilostazol (Pletal) and its metabolites. Continue reading Interaction of Ginkgo biloba with antiplatelet drugs

Lower fasting blood sugar levels associated with marijuana use

Marijuana1-150x150This study has been picked up by just about every news organization — far different from recent study results on adverse effects of marijuana.

Since this site is fair and balance, here are the results from University of Nebraska College of Medicine, Omaha, on the relationship between marijuana use and fasting insulin, glucose, and insulin resistance. Continue reading Lower fasting blood sugar levels associated with marijuana use

Cyclic nausea and vomiting due to marijuana use

As legislators dive headlong into legalization of marijuana, there is growing evidence that they may be harming their most loyal constituents.

Researchers at Temple University Hospital, in Philadelphia, Pennsylvania, reviewed what has become known as Cannabinoid Hyperemesis (severe and excessive vomiting) Syndrome.

As you read this summary it might be useful to consider the value of Pennsylvania detoxification programs.

Continue reading Cyclic nausea and vomiting due to marijuana use