The C.A.M. Report
Complementary and Alternative Medicine: Fair, Balanced, and to the Point
  • About this web log

    This blog is intended as an objective and dispassionate source of information on the latest CAM research. Since my background is in pharmacy and allopathic medicine, I view all CAM as advancing through the development pipeline to eventually become integrated into mainstream medical practice. Some will succeed while others fail. But all are treated fairly here.

  • About the author

    John Russo, Jr., PharmD, is president of The MedCom Resource, Inc. Previously, he was senior vice president of medical communications at, a complementary and alternative medicine website.

  • Common sense considerations

    The material on this weblog is for informational purposes. It is not medical advice or counsel. Be smart, consult your health professional before using CAM.

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    Enriched skim milk powder to prevent gout flares

    Laboratory studies have identified two dairy fractions, glycomacropeptide (GMP) and G600 milk fat extract (G600), with anti-inflammatory effects in models of acute gout.

    Researchers at the University of Auckland, in New Zealand, tested the concept in humans.

    First, the details.

    • 120 patients with recurrent gout flares were randomly assigned to a treatment group for 3 months.
      • Lactose powder control
      • Skim milk powder (SMP) control
      • SMP enriched with GMP and G600 (SMP/GMP/G600)
    • Changes in the frequency of gout flares were recorded.
    • GMP is a carbohydrate-rich casein peptide.

    And, the results.

    • The frequency of gout flares was reduced in all groups compared to before the study.
      • There was a significantly greater reduction in gout flares in the SMP/GMP/G600 group vs lactose.
    • Following treatment with SMP/GMP/G600 greater improvements were also observed in pain and fractional excretion of uric acid.
    • There was no significant difference in improvement in tender joint count.
    • Similar adverse event rates and discontinuation rates were observed between the three groups.

    The bottom line?

    The authors concluded, “In patients with gout… [the findings] suggest that SMP enriched with GMP and G600 may reduce the frequency of gout flares.

    The response to treatment with SMP/GMP/G600 might in part be due to G600 inhibition of IL-8 inflammatory activity, which is also inhibited by colchicine — used to treat gout flares.

    1/31/12 20:59 JR

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