The C.A.M. Report
Complementary and Alternative Medicine: Fair, Balanced, and to the Point
  • About this web log

    This blog is intended as an objective and dispassionate source of information on the latest CAM research. Since my background is in pharmacy and allopathic medicine, I view all CAM as advancing through the development pipeline to eventually become integrated into mainstream medical practice. Some will succeed while others fail. But all are treated fairly here.

  • About the author

    John Russo, Jr., PharmD, is president of The MedCom Resource, Inc. Previously, he was senior vice president of medical communications at, a complementary and alternative medicine website.

  • Common sense considerations

    The material on this weblog is for informational purposes. It is not medical advice or counsel. Be smart, consult your health professional before using CAM.

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    Effect of EstroG-100 on menopausal symptoms

    Researchers in Korea and the US studied EstroG-100 — a mixture of standardized extracts of Cynanchum wilfordii, Phlomis umbrosa and Angelica gigas.

    First, the details.

    • 64 pre-, peri- and postmenopausal White Hispanic, White non-Hispanic, and African American women were randomly assigned to a treatment group for 12?weeks.
      • EstroG-100
      • Placebo group
    • Changes in the Kupperman menopause index (evaluates the severity of menopausal symptoms), and vaginal dryness were measured.
    • Neither the researchers nor patents were aware of the treatment given — double blind.

    And, the results.

    • The average Kupperman menopause index score was significantly reduced in the EstroG-100 group (30 to 11) compared with the placebo group (29 to 24) at week 12.
    • Vasomotor symptoms, paresthesia (numbness), insomnia, nervousness, melancholia, vertigo, fatigue, and rheumatic pain were significantly improved in the EstroG-100 group vs the placebo group.
    • Statistically significant improvement in vaginal dryness in the EstroG-100 group was also observed vs the placebo group.

    The bottom line?

    The authors concluded, “EstroG-100 significantly improved the menopausal symptoms of pre-, peri- and post-menopausal women without weight gain or any serious side effects.”

    Cynanchum wilfordii is a perennial herb whose roots have been used in Korea to treat insomnia and anxiety. Phlomis umbrosa purportedly has protective effects on the liver and is used as a haemostatic and to treat athlete’s foot. Angelica gigas is used in Korea to treat “women’s diseases.”

    This appears to be the first published study of EstroG.

    9/7/11 23:02 JR

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