The C.A.M. Report
Complementary and Alternative Medicine: Fair, Balanced, and to the Point
  • About this web log

    This blog is intended as an objective and dispassionate source of information on the latest CAM research. Since my background is in pharmacy and allopathic medicine, I view all CAM as advancing through the development pipeline to eventually become integrated into mainstream medical practice. Some will succeed while others fail. But all are treated fairly here.

  • About the author

    John Russo, Jr., PharmD, is president of The MedCom Resource, Inc. Previously, he was senior vice president of medical communications at, a complementary and alternative medicine website.

  • Common sense considerations

    The material on this weblog is for informational purposes. It is not medical advice or counsel. Be smart, consult your health professional before using CAM.

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    Fructose-rich beverages and the risk of gout

    Researchers at Boston University School of Medicine examined the relationship and reported a “modest” increase in risk.

    First, the details.

    • 78,906 women with no history of gout provided information on their intake of beverages using validated food frequency questionnaires.
    • These women were participants in the Nurses’ Health Study, which spanned 22 years (1984-2006).
    • Cases of gout that met the American College of Rheumatology criteria were recorded.

    And, the results.

    • There were 778 cases of gout were reported.
    • Sugar
      • Compared with the drinking less than 1 serving per month of sugar-sweetened soda, drinking 1 or at least 2 servings per day was associated with a significant 1.74- and 2.39-fold increased risk for gout, respectively.
    • Orange juice
      • Drinking orange juice was associated with a significant 1.41- and 2.42-fold increased risk, respectively.
    • Diet drinks
      • Drinking diet soft drinks was not associated with the risk for gout.
    • Fructose
      • Compared with the lowest fructose intake, the risk for gout in women with the highest intake was a significant 1.62.
      • This indicates a risk difference of 28 cases per 100,000 person-years.

    The bottom line?

    The authors concluded, “Consumption of fructose-rich beverages is associated with an increased risk of incident gout, although… the risk of gout … is likely modest given the low incidence rate among women.”

    The overall negative health effect of fructose is expected to be larger in women with a history of gout.

    The authors explain that fructose induces uric acid production by increasing the reaction of adenosine triphosphate (ATP; stores chemical energy) to adenosine monophosphate (AMP), which is precursor to making uric acid.

    11/19/10 19:25 JR

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