The C.A.M. Report
Complementary and Alternative Medicine: Fair, Balanced, and to the Point
  • About this web log

    This blog is intended as an objective and dispassionate source of information on the latest CAM research. Since my background is in pharmacy and allopathic medicine, I view all CAM as advancing through the development pipeline to eventually become integrated into mainstream medical practice. Some will succeed while others fail. But all are treated fairly here.

  • About the author

    John Russo, Jr., PharmD, is president of The MedCom Resource, Inc. Previously, he was senior vice president of medical communications at www.Vicus.com, a complementary and alternative medicine website.

  • Common sense considerations

    The material on this weblog is for informational purposes. It is not medical advice or counsel. Be smart, consult your health professional before using CAM.

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  • Recent Comments

    Risk of liver toxicity from kava formulations

    Does it matter whether the kava formulation is an aqueous, ethanolic, or acetonic extract?

    Researchers from the Johann Wolfgang Goethe-University of Frankfurt/Main, in Germany tell us the risk of liver toxicity exists with all forms of kava.

    First, the details.

    • The risk of liver toxicity by kava and kava/herbs mixtures was assessed using an aqueous extract of kava.
    • The findings were compared to 2 other extraction solutions.

    And, the results.

    • Causality was established in 5 patients for aqueous kava extracts and kava/herbs mixtures.
    • A comparison with 9 patients with established causality of liver toxicity by ethanolic and acetonic kava extracts revealed that the clinical picture in all 14 patients was similar, independent of whether aqueous, ethanolic, or acetonic kava extracts or kava/herbs mixtures were used.

    The bottom line?
    It appears that the risk of liver toxicity is related to the kava plant itself and not to the method of extracting the active components.

    More about “causality” is discussed here. Most case reports of drug toxicity concern “suspected” adverse drug reactions. They are rarely specific for the drug, diagnostic tests are usually absent, and readministering the suspected drug is rarely ethically justified. “Causality assessment” offers a systematic approach to estimating the likelihood that the drug (herb) in questions was responsible for the adverse effect reported.

    6/13/09 16:22 JR

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