Reduce stress. Reduce pain?
 Might reducing negative emotions explain placebo-associated pain reduction?
And, should the stress response be included in every placebo-controlled study?
First, the details.
- 63 students were tested on 2 separate days.
- One day they took capsules containing lactose, but were told the capsules contained a potent painkiller.
- The next time, they were told the same thing, but no capsules were taken.
- The volunteers didn’t know the treatment given — single-blinded.
- Pain was induced by placing a thermal probe (+46°C, 115°F) on the forearm for 240 seconds.
- Electrocardiogram (ECG) was used to measure heart rate variability.
- Subjective measurements included pain intensity, pain unpleasantness, stress, arousal, and mood.
And, the results.
- There was a placebo effect on pain intensity that was accompanied by a reduction in subjective stress and heart activity.
- These were the only factors independently associated with pain intensity.
- Reduced subjective stress was the only predictor for the placebo analgesic response.
The bottom line?
The authors concluded, “Reduced negative emotional activation could be a mechanism in placebo analgesia.”
My take is that every placebo-controlled study should include ECG monitoring in order to account for any response that might be associated with stress-reduction.
10/3/08 20:15 JR