The C.A.M. Report
Complementary and Alternative Medicine: Fair, Balanced, and to the Point
  • About this web log

    This blog is intended as an objective and dispassionate source of information on the latest CAM research. Since my background is in pharmacy and allopathic medicine, I view all CAM as advancing through the development pipeline to eventually become integrated into mainstream medical practice. Some will succeed while others fail. But all are treated fairly here.

  • About the author

    John Russo, Jr., PharmD, is president of The MedCom Resource, Inc. Previously, he was senior vice president of medical communications at www.Vicus.com, a complementary and alternative medicine website.

  • Common sense considerations

    The material on this weblog is for informational purposes. It is not medical advice or counsel. Be smart, consult your health professional before using CAM.

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  • Recent Comments

    Update: Grapefruit juice:Rx drug interactions

    According to Dr. William McCloskey, the likelihood of drug:grapefruit juice interactions having a negative effect on a patient’s response to the drug has not been clearly established.

    This might be due to the fact that many drugs affected by grapefruit juice have a wide therapeutic index. In other words, toxic blood levels are so much higher than the blood levels needed to achieve an effective treatment dose that any increase caused by grapefruit juice is not sufficient to reach toxicity.

    That’s not to say there is no risk of a grapefruit juice:drug interaction.

    Unfortunately, the source article has been deleted, but here’s the bottom line. If you take any of the drugs listed below and feel you must drink grapefruit juice, first discuss it with your doctor.

    • Amiodarone (Cordarone)
    • Atorvastatin (Lipitor)
    • Buspirone (Buspar)
    • Carbamazepine (Tegretol)
    • Clomipramine (Anafranil)
    • Cyclosporine (Sandimmune, Neoral)
    • Diazepam (Valium)
    • Etoposide (VePesid)
    • Felodipine (Plendil)
    • Fexofenadine (Allegra)
    • Itraconazole (Sporanox)
    • Lovastatin (Mevacor)
    • Methadone (Methadose)
    • Midazolam (Versed)
    • Nicardipine (Cardene)
    • Nifedipine (Procardia)
    • Nimodipine (Nimotop)
    • Nisoldipine (Sular)
    • Saquinavir (Invirase)
    • Sildenafil (Viagra)
    • Simvastatin (Zocor)
    • Triazolam (Halcion)

    3/19/08 11:13 JR

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