The C.A.M. Report
Complementary and Alternative Medicine: Fair, Balanced, and to the Point
  • About this web log

    This blog is intended as an objective and dispassionate source of information on the latest CAM research. Since my background is in pharmacy and allopathic medicine, I view all CAM as advancing through the development pipeline to eventually become integrated into mainstream medical practice. Some will succeed while others fail. But all are treated fairly here.

  • About the author

    John Russo, Jr., PharmD, is president of The MedCom Resource, Inc. Previously, he was senior vice president of medical communications at www.Vicus.com, a complementary and alternative medicine website.

  • Common sense considerations

    The material on this weblog is for informational purposes. It is not medical advice or counsel. Be smart, consult your health professional before using CAM.

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    If you found the information here helpful, please consider supporting this site.If you found the information here helpful, please consider supporting this site.

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  • Recent Comments

    Coenzyme Q10 to prevent muscle pain or tenderness caused by statins

    Myalgia (muscle pain or tenderness) is the most common side effect of taking statins to treat high cholesterol blood levels. It’s also the biggest reason to lower the dose or stop treatment with these important drugs.

    There’s some support that the muscle-related side effects of statins could be due to a statin-induced deficiency in coenzyme Q10.

    But not here.

    First, the details.

    • 44 patients were randomly assigned to take coenzyme Q10 (200 mg/day) or placebo for 12 weeks.
    • At the same time all participants received increasing doses of simvastatin (Zocor) from 10 mg to a maximum of 40 mg/day.
    • The presence and extent of myalgia was assessed using a visual analogue scale.

    And, the results.

    • There were no significant differences in myalgia score.
    • No difference in the number of patients who could tolerate simvastatin 40 mg.
    • No difference in the number of patients remaining on therapy.

    The bottom line?
    The authors concluded, “Coenzyme Q10 supplementation did not improve statin tolerance or myalgia.”

    However, they recommend further studies.

    Myalgia during treatment with simvastatin occurs in just 1.5% of patients. It would be surprising to find anything significant in a population of just 44 patients.

    Also, the correct dosage of coenzyme Q10 is in dispute. Last year Japan’s Ministry of Health, Labour and Welfare asked manufacturers to determine the correct dose. This year it announced that 300 mg is a “reasonably safe maximum daily dose.” Although confirmation and the official announcement has not been made.

    12/1/07 10:14 JR

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